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Pharmacological effects and indications of Enoxaparin sodium
2021-07-20 09:15:52

Enoxaparin sodium is a low molecular weight heparin used as an anticoagulant for the prevention and treatment of deep vein thrombosis or pulmonary embolism. Enoxaparin sodium is a white or almost white powder, tasteless, hygroscopic, soluble in water, insoluble in organic solvents such as ethanol and acetone. It has a strong negative charge in aqueous solution and can combine with some cations to form a molecular complex. The aqueous solution is more stable at pH 7.

Enoxaparin sodium is a low molecular weight heparin preparation, which can make the ratio of anticoagulant factor Ⅹa and Ⅱa activity greater than 4, thus exerting a strong antithrombotic function and a certain thrombolytic effect. There was no significant change in the total coagulation index at the recommended dose, and the platelet aggregation time and the binding to fibrinogen were also unchanged. Although low molecular weight heparin (LMWH) is suitable for all heparin fragments with a molecular weight of less than 8000 Da, the effect of each fragment still depends on the molecular weight. In vitro studies comparing enoxaparin sodium (with a molecular weight of 4000~6000 Da) and unisolated heparin showed that, according to their molecular weight, compared with the effect of unisolated heparin, the inhibitory effect of enoxaparin sodium on thrombin was reduced by approximately 5 times. In vivo studies have also shown that subcutaneous application of heparin, the activated partial thromboplastin time (APTT) is significantly longer than subcutaneous application of enoxaparin sodium.


1. It is mainly used to prevent the formation of venous thrombosis after plastic surgery and general surgery and blood coagulation during cardiopulmonary bypass during hemodialysis.

2. Enoxaparin sodium can prevent deep vein thrombosis and pulmonary embolism, and treat deep vein thrombosis that has formed.