South Korea DMF panheparin sodium manufacturer

2023-12-31 09:59:42

1. Heparin combined with the following drugs can increase the risk of bleeding: coumarin and its derivatives, aspirin and non steroidal anti-inflammatory analgesics, dipyridamole, dextran, adrenocortical hormone, adrenocorticotropic hormone, tissue plasminogen activator, urokinase, streptokinase, etc.

2. Heparin combined with sodium bicarbonate, sodium lactate and other drugs to correct acidosis can promote the anticoagulant effect of heparin.

3. The mixed injection of heparin and hyaluronidase can not only reduce the pain of intramuscular injection, but also promote the absorption of heparin. However, heparin can inhibit the activity of hyaluronidase, so the two drugs should be combined temporarily, and should not be stored for a long time after mixing.

4. Heparin can interact with insulin receptor to change the binding and action of insulin.

5. It can not be combined with basic drugs.

Note: the above contents are only for introduction, and the use of drugs must be carried out under the guidance of doctors in regular hospitals.

Heparin, also known as heparin sodium, standard heparin, ungrouped heparin, heparin, regular heparin [RH], standard heparin [sh], unbroked sodium heparin [UFH].

Heparin is an anionic sulfated aminoglucan. It is a heterogeneous substance with an average molecular weight of 12 000 and exists on the surface of many main cells. Commercial heparin sodium was extracted from pig intestines or cattle lungs. Heparin is composed of non branched low sugar chains with different lengths. D-glucosamine and D-glucuronic acid (or l-iduronic acid) are linked by glycosidic chains to form the basic disaccharide repeat of heparin chain. There are many substitutions in the repeated disaccharide sequence. It includes: R1: H or - oso3 group, R2: SO3 or - coch3 group, so that a few disaccharides form pentose sequence. The molecular weight of heparin is 3-30kda (most chains are 13-15kda).

Although the length of polypeptide chain is different, only one third of polypeptide chain in heparin chain contains pentose structure which can bind to at Ⅲ. Pentose structure is randomly distributed in heparin chain, which is the anticoagulant and antithrombotic functional unit of heparin.